Dr. Endemann's Background

Gerda Endemann is a scientist and a nutrition educator in the San Francisco Bay Area. She holds a B.S. in Nutrition from the University of California at Berkeley and a Ph.D. in Nutritional Biochemistry from the Massachusetts Institute of Technology. For more than 20 years, she has conducted basic research on heart disease, inflammation and cancer in academic laboratories and in the biotechnology industry. She is an author of numerous publications on these diseases in scientific journals.
photo by Marina Brodskaya

Education
Ph.D., 1982 Massachusetts Institute of Technology, Cambridge, MA
Major: Nutritional Biochemistry and Metabolism
B.S., 1977 University of California, Berkeley, (highest honors)
Major: Food, Nutrition and Dietetics

Professional experience
1998 - 2002 Senior Research Scientist, Stanford University School of Medicine
1989 - 1997 Senior Scientist and Scientist, Scios Inc., (formerly California Biotechnology Inc.)
1985 - 1989 Postdoctoral Fellow, Tufts University Medical School and Stanford University
1982 - 1985 Postdoctoral Fellow, Harvard School of Public Health and Brandeis University
1977 - 1978 Research Assistant, University of California, Berkeley

Awards and honors
1991 Principal Investigator, NIH SBIR Phase I Grant: "Molecular cloning of cDNA encoding oxidized-LDL receptor."
1986 Leukemia Society of America Postdoctoral Fellowship
1986 American Heart Association Postdoctoral Fellowship
1983 National Institutes of Health Postdoctoral Fellowship
1979 National Science Foundation Graduate Fellowship
1978 Ida M. Green Graduate Fellowship
1975 Torch and Shield Scholarship
1973 California State Scholarship
Member, Phi Beta Kappa
Regents' Scholar, University of California

Professional organizations
American Society for Nutrition
American Society for Biochemistry and Molecular Biology

PUBLICATIONS
1. Forte, T. M., Nordhausen, R. W., Nichols, A. V., Endemann, G., Miljanich, P., and Bell- Quint, J. J. Dissociaton of apolipoprotein A-I from porcine and bovine high- density lipoproteins by guanidine hydrochloride. Biochim. Biophys. Acta. 573: 451-463 (1979).
2. Tinoco, J., Endemann, G., Medwadowski, B., Miljanich, P., and Williams, M. A. Ethanolamine kinase activity and compositions of diacylglycerols, phophatidylcholines and phosphatidylethanolamines in livers of choline-deficient rats. Lipids 14: 968-974 (1979).
3. Tinoco, J., Endemann, G., Hincenbergs, I., Medwadowski, B., Miljanich, P., and Williams, M. A. Effects of linolenic acid deficiency on the fatty acid patterns in plasma and liver cholesteryl esters, triglycerides and phospholipids in female rats. J. Nutr. 110: 1497-1505 (1980).
4. Endemann, G., and Brunengraber, H. The source of acetyl Coenzyme A for acetylcholine synthesis in the perfused rat phrenic nerve-hemidiaphragm. J. Biol. Chem. 255: 11091-11093 (1980).
5. Endemann, G., Goetz, P. G., Edmond, J., and Brunengraber, H. Lipogenesis from ketone bodies in the isolated perfused rat liver: Evidence for the cytosolic activation of acetoacetate. J. Biol. Chem. 257: 3434-3440 (1982).
6. Weinstock, S. B., Kopito, R.R., Endemann, G., Tomera, J. F., Marinier, E., Murray, D. M., and Brunengraber, H. The shunt pathway of mevalonate metabolism in the isolated perfused rat liver. J. Biol. Chem. 259: 8939-8944 (1984).
7. Alderson, L. M., Endemann, G., Lindsey, S., Pronczuk, A., Hoover, R. C., and Hayes, K. C. Low-density lipoprotein enhances monocyte adhesion to endothelial cells in vitro. Am. J. Pathol. 123: 334-342 (1986).
8. Cantley, L., Whitman, M., Kaplan, D. R., Chahwala, S. B., Fleischman, L., Endemann, G., Schaffhausen, B. S., and Roberts, T. M. Phosphatidylinositol kinases and cell transformation. In Critical Molecular Determinants of Carcinogenesis, Proceedings of the 39th Annual Symposium on Fundamental Cancer Research, pp. 165-172 (1986).
9. Endemann, G., Pronzcuk, A., Friedman, G., Lindsey, S., Alderson, L., and Hayes, K. C. Monocyte adherence to endothelial cells in vitro is increased by b-VLDL. Am. J. Pathol. 126: 1-6 (1987).
10. Endemann, G., Goetz, P. G., Tomera, J. F., Rand, W. M., Desrochers, S., and Brunengraber, H. Lipogenesis from ketone bodies in the perfused liver: Effects of acetate and ethanol. Biochem. Cell Biol. 65: 989-996 (1987).
11. Whitman, M., Kaplan, D., Endemann, G., Roberts, T., and Cantley, L. Characterization of multiple phosphatidylinositol kinases in murine fibroblasts and bovine brain. In Inositol Lipids in Signaling, Cold Spring Harbor Laboratory, NY, pp. 151-155 (1987).
12. Endemann, G., Dunn, S. N., and Cantley, L. C. Bovine brain contains two types of phosphatidylinositol kinase. Biochemistry 26: 6845-6852 (1987).
13. Freed, L. E., Endemann, G., Tomera, J. F., Gavino, V. C., and Brunengraber, H. Lipogenesis from ketone bodies in perfused livers from streptozotocin-diabetic rats. Diabetes 37: 50-55 (1988).
14. Cantley, L., Whitman, M., Kaplan, D. R., Chahwala, S. ., Fleischman, L., Endemann, G., Schaffhausen, B. S., and Roberts, T. M. Oncogenes and phosphatidylinositol turnover. In Modulation of Liver Cell Expression, Proceedings of Falk Symposium No. 43, pp. 265-271 (1988).
15. Endemann, G., Yonezawa, K., and Roth, R. A. Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase. J. Biol. Chem. 265: 396-400 (1990).
16. Yonezawa, K., Endemann, G., Kovacina, K. S., Chin, J. E., Stover, C., and Roth, R. A. Substrates of the insulin receptor kinase. In The Biology and Medicine of Signal Transduction, Nishizuka, Y. et al, eds, Raven Press, New York, pp. 266-272 (1990).
17. Endemann, G., Graziani, A., and Cantley, L. C. A monoclonal antibody distinguishes two different phosphatidylinositol 4-kinases from brain. Biochem. J. 273: 63- 66 (1991).
18. Graziani, A., Ling, L. E., Endemann, G., Carpenter, C. L., and Cantley, L.C. Purification and characterization of human erythrocyte phosphatidylinositol 4- kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-mono- phosphate 4-kinase are distinct enzymes. Biochem. J. 284: 399-45 (1992).
19. Stanton, L., White, R. T., Bryant, C., Protter, A. A., and Endemann, G. A macrophage Fc receptor for IgG is also a receptor for oxidized-low density lipoprotein. J. Biol. Chem. 267: 22446-22451 (1992).
20. Endemann, G., Stanton, L. W., Madden, K. S., Bryant, C. M., White, R. T., and Protter, A. CD36 is a receptor for oxidized-low density lipoprotein. J. Biol. Chem. 268: 11811-11816 (1993).
21. Kauffmann-Zeh, A., Klinger, R., Endemann, G., Waterfield, M. D., Wetzker, R., and Hsuan, J. J. Regulation of human type II phosphatidylinositol kinase activity by epidermal growth factor-dependent phosphorylation and receptor association. J. Biol. Chem. 269: 31243-31251 (1994).
22. Hamilton, G. S., Mewshaw, R. E., Bryant, C. M., Feng, Y., Endemann, G., Madden, K., Janczak, J. E., Perumattam, J., Stanton, L. W., Yang, X., Yin, Z., Venkataramen, B., and Liu, D. Y. S. Fluorenylalkanoic and benzoic acids as novel inhibitors of cell adhesion processes in leukocytes. J. Med. Chem. 38: 1650-1656 (1995).
23. Endemann, G., Feng, Y., Bryant, C. M., Hamilton, G. S., Perumattam, J., Mewshaw, R. E., and Liu, D.Y. Novel anti-inflammatory compounds prevent Mac-1 dependent neutrophil adhesion without blocking activation induced changes in Mac-1. J. Pharmacol. Exp. Ther. 276: 5-12 (1996).
24. Endemann, G., Abe, Y., Bryant, C. M., Feng, Y., Smith, C. W., and Liu, D. Y. Novel anti-inflammatory compounds induce shedding of L-selectin and block primary capture of neutrophils under flow conditions. J. Immunol. 158: 4879-4885 (1997).
25. Hennessy L. K., Kunitake S. T., Jarvis M., Hamilton R. L., Endeman G., Protter A., Kane J. P. Isolation of subpopulations of high density lipoproteins: three particle species containing apoE and two species devoid of apoE that have affinity for heparin. J Lipid Res. 38: 1859-68 (1997).
26. Feng, Y., Chung, D., Scardina, J., Garrard, L., Abraham, J., McEnroe, G., Lim D., McFadden, K., Guzetta, A., Lam, A., Liu, D. Y., and Endemann, G. Peptides derived from CDR’s of anti-Mac-1 antibodies block Mac-1 function. J. Biol. Chem. 273: 5625-5630 (1998).
27. Endemann, G. Fat is not the Enemy. Word Association Publishers, Tarentum, PA (2002).
28. Endemann, G., Schechtman, D., and Mochly-Rosen, D. Cytotoxicity of pEGFP vector is due to residues encoded by the multiple cloning site. Anal. Biochem. 313: 345-347 (2003).
29. Endemann, G., and Mochly-Rosen, D. Methods for Detecting Binding Proteins. Methods Mol. Biol. 233: 307-325 (2003).
30. Faridi, J., Wang, L., Endemann, G. and Roth, R. A. Expression of constitutively active Akt3 in MCF-7 breast cancer cells reverses the estrogen and tamoxifen responsivity of these cells in vivo. Clin. Cancer Res. 9: 2933-2939 (2003).
31. Souroujon, M. C., Yao, L., Chen, H., Endemann, G., Khaner, H., Geeraert, V., Schechtman, D., Gordon, A. S., Diamond, I., and Mochly-Rosen, D. State-specific monoclonal antibodies identify an intermediate state in epsilon protein kinase C activation. J. Biol. Chem. 279: 17617-17624 (2004).